Pengaruh Variasi Konsentrasi Polivinil Pirolidon K-30 sebagai Pengikat dalam Pembuatan Oral Fast Dsissolving Tablet Domperidon Base
DOI:
https://doi.org/10.61609/afamedis.v2i1.28Keywords:
Domperidon Base, PVP K-30, Physical Quality Test, Oral Fast Dissolving TabletsAbstract
Domperidone base as anti-nausea or vomiting drug mostly available in conventional tablets forms has weakness in swallowing tablets and requires drinking water. Oral fast dissolving tablets are a solution to this problem. Oral fast dissolving tablets with variations in the concentration of PVP K-30 to determine effect of the tablet physical quality test and good physical quality results. The wet granulation method was used to improve the flow properties by mixing the binder mucilago with the inner phase. Test of physical quality of tablets, weight uniformity, size uniformity, hardness, friability, disintegration time, and unifomity of content. The results showed a significant difference in friability and disitegration time. The conclusion based on the results of the study showed that the variation in the concentration of PVP K-30 on the difference in the physical quality test of tablets and the 2% concentration of PVP K-30 gave good results
Downloads
References
[2] Ansel, H.C.. 1989. Pengantar Bentuk Sediaan Farmasi, Edisi Keempat, Diterjemahkan oleh Farida Ibrahim, Asmanizar, Iis Aisyah, Jakarta: UI Press.
[3] Sanjay, P.D., Deepak, M., and Bhanudas, S.R. Liquisolid Technology: Technique for Formulation with Enhanced Bioavailability, World Journal of Pharmacy and Pharmaceutical Sciences. 2013. 3(1): 368-387.
[4] Agoes, Goeswin. 2012. Sediaan Farmasi Likuida dan Semisolida. Bandung: ITB Press.
[5] Muktamar, Tin Ridha. 2007. Pengaruh Penambahan PVP (Polivinil Pirolidon) Sebagai Bahan Pengikat Terhadap Sifat Fisik dan Profil Disolusi Tablet Parasetamol Dengan Metode Granulasi Basah. Surakarta: Universitas Muhammadiyah.
[6] Rowe, R. C., P. J. Sheskey, and M. E. Quinn. 2009. Handbook of Pharmaceutical Excipients, Sixth Edition, London: Pharmaceutical Press
[7] Departemen Kesehatan RI. 2005. Ilmu Resep Teori. Jakarta: Depkes RI.
[8] Kumar, Shobhit, Satish Kumar Gupta dan Pramod Kumar Sharma. A Review on Recent Trends in Oral Drug Delvery-Fast Dissolving Formulation Technology, Advances in Biological Research 6 (1): 06-13,2012 ISSN 1992-0067 IDOSI Publications, 2012.
[9] Kumar, V., A. K. Abbas, J. C. Aster, 2015. Buku Ajar Patologi Robbins, Edisi 9. Singapura: Elsevier Saunders.
[10] Ratnaparkhi, Mukesh P., Dr. G.P.Mohanta dan Dr. Lokesh Upadhyay. Review On Fast Dissolving Tablet. Journal of Pharmacy Research. 2008. 2 (1) January 2009.
[11] Nagar, Priyanka, Kusum Singh, Iti Chauhan, Madhu Verma, Mohd Yasir, Azad Khan, Rajat Sharma dan Nandini Gupta. 2011. Orally Disintegrating Tablets: Formulation, Preparation Techniques and Evaluation. Journal of Applied Pharmaceutical Science. 2011.01(04):35-45. ISSN 2231-3354
[12] Rahane, R.D. dan Dr. Punit R. Rachh. 2018. A Review On Fast Dissolving Tablet. Diakses pada 28 Juli 2020. Journal of Drug Delivery and Therapeutics. 2018. 8(5):50-55. DOI: http://dx.doi.org/10.22270/jddt.v8i5.1888
